Indexado en

Citaciones

Cited 5 times in

Cited 3 times in

Grant support

This research was supported by the Institute for Tropical Health funders (Obra Social la CAIXA-LCF/PR/PR13/11080005-and Fundacion Caja Navarra, Fundacion Maria Francisca de Roviralta, Ubesol and Inversiones Garcilaso de la Vega S.L.) and grants MINECO (AGL2014-58795-C4-1-R). B.A.A. is the recipient of the Ph.D. Fellowship BES-2015-075609 funded by the MINECO.

Análisis de autorías institucional

Compartir

Rev1 wbdR tagged vaccines against Brucella ovis

Publicado en:Veterinary Research. 50 (1): 95-95 - 2019-11-15 50(1), doi: 10.1186/s13567-019-0714-3

De Miguel Mj; Muñoz Pm;

Afiliaciones

Resúmen

Resúmen: © 2019 The Author(s). Sheep brucellosis is a worldwide extended disease caused by B. melitensis and B. ovis, two species respectively carrying smooth or rough lipopolysaccharide. Vaccine B. melitensis Rev1 is used against B. melitensis and B. ovis but induces an anti-smooth-lipopolysaccharide response interfering with B. melitensis serodiagnosis, which precludes its use against B. ovis where B. melitensis is absent. In mice, Rev1 deleted in wbkC (Brucella lipopolysaccharide formyl-transferase) and carrying wbdR (E. coli acetyl-transferase) triggered antibodies that could be differentiated from those evoked by wild-type strains, was comparatively attenuated and protected against B. ovis, suggesting its potential as a B. ovis vaccine.

Palabras clave: Biovars; Diagnosis; Efficacy; Heterogeneity; Melitensis infection; Mutants; Polysaccharide; Serological tests; Sheep; Smooth-lipopolysaccharide

Indicios de calidad