Grant support

This research was supported by the Institute for Tropical Health funders (Obra Social la CAIXA-LCF/PR/PR13/11080005-and Fundacion Caja Navarra, Fundacion Maria Francisca de Roviralta, Ubesol and Inversiones Garcilaso de la Vega S.L.) and grants MINECO (AGL2014-58795-C4-1-R). B.A.A. is the recipient of the Ph.D. Fellowship BES-2015-075609 funded by the MINECO.

Análisis de autorías institucional
De Miguel Mj - Autor o Coautor
Muñoz Pm - Autor o Coautor
Publicaciones > Artículo

Rev1 wbdR tagged vaccines against Brucella ovis

Publicado en:Veterinary Research. 50 (1): 95-95 - 2019-11-15 50(1), doi: 10.1186/s13567-019-0714-3

De Miguel Mj; Muñoz Pm;


Centro de Investigación y Tecnología Agroalimentaria de Aragón - Entidad de origen
Inst Invest Sanitaria Navarra IdiSNA, Inst Salud Trop ISTUN, C Irunlarrea 1, Pamplona 31008, Spain - Autor o Coautor
Institute for Tropical Health (Fundacion Caja Navarra) - Financiador
Institute for Tropical Health (Fundacion Maria Francisca de Roviralta) - Financiador
Institute for Tropical Health (Inversiones Garcilaso de la Vega S.L.) - Financiador
Institute for Tropical Health (Obra Social la) - Financiador
Institute for Tropical Health (Ubesol) - Financiador
MINECO - Financiador
Univ Navarra, Dept Microbiol & Parasitol, C Irunlarrea 1, Pamplona 31008, Spain - Autor o Coautor
Univ Zaragoza, Unidad Prod & Sanidad Anim, IA2, CITA, Ave Montanana 930, Zaragoza 50059, Spain - Autor o Coautor
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Resúmen: © 2019 The Author(s). Sheep brucellosis is a worldwide extended disease caused by B. melitensis and B. ovis, two species respectively carrying smooth or rough lipopolysaccharide. Vaccine B. melitensis Rev1 is used against B. melitensis and B. ovis but induces an anti-smooth-lipopolysaccharide response interfering with B. melitensis serodiagnosis, which precludes its use against B. ovis where B. melitensis is absent. In mice, Rev1 deleted in wbkC (Brucella lipopolysaccharide formyl-transferase) and carrying wbdR (E. coli acetyl-transferase) triggered antibodies that could be differentiated from those evoked by wild-type strains, was comparatively attenuated and protected against B. ovis, suggesting its potential as a B. ovis vaccine.

Palabras clave: Biovars; Diagnosis; Efficacy; Heterogeneity; Melitensis infection; Mutants; Polysaccharide; Serological tests; Sheep; Smooth-lipopolysaccharide

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