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Grant support

This research was supported by the Institute for Tropical Health funders (Obra Social la CAIXA-LCF/PR/PR13/11080005-and Fundacion Caja Navarra, Fundacion Maria Francisca de Roviralta, Ubesol and Inversiones Garcilaso de la Vega S.L.) and grants MINECO (AGL2014-58795-C4-1-R). B.A.A. is the recipient of the Ph.D. Fellowship BES-2015-075609 funded by the MINECO.

Analysis of institutional authors

De Miguel MjAuthorMuñoz PmAuthor

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November 18, 2019
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Rev1 wbdR tagged vaccines against Brucella ovis

Publicated to:Veterinary Research. 50 (1): 95-95 - 2019-11-15 50(1), DOI: 10.1186/s13567-019-0714-3

Authors: Aragon-Aranda, Beatriz; de Miguel, Maria Jesus; Martinez-Gomez, Estrella; Zuniga-Ripa, Amaia; Salvador-Bescos, Miriam; Moriyon, Ignacio; Iriarte, Maite; Munoz, Pilar M; Conde-Alvarez, Raquel

Affiliations

Inst Invest Sanitaria Navarra IdiSNA, Inst Salud Trop ISTUN, C Irunlarrea 1, Pamplona 31008, Spain - Author
Univ Navarra, Dept Microbiol & Parasitol, C Irunlarrea 1, Pamplona 31008, Spain - Author
Univ Zaragoza, Unidad Prod & Sanidad Anim, IA2, CITA, Ave Montanana 930, Zaragoza 50059, Spain - Author

Abstract

© 2019 The Author(s). Sheep brucellosis is a worldwide extended disease caused by B. melitensis and B. ovis, two species respectively carrying smooth or rough lipopolysaccharide. Vaccine B. melitensis Rev1 is used against B. melitensis and B. ovis but induces an anti-smooth-lipopolysaccharide response interfering with B. melitensis serodiagnosis, which precludes its use against B. ovis where B. melitensis is absent. In mice, Rev1 deleted in wbkC (Brucella lipopolysaccharide formyl-transferase) and carrying wbdR (E. coli acetyl-transferase) triggered antibodies that could be differentiated from those evoked by wild-type strains, was comparatively attenuated and protected against B. ovis, suggesting its potential as a B. ovis vaccine.

Keywords

Amino sugarsAnimalsBiovarsBrucella ovisBrucella vaccineBrucellosisDiagnosisEfficacyFemaleHeterogeneityMelitensis infectionMiceMice, inbred balb cMutantsN-acetylperosaminePolysaccharidePolysaccharidesSerological testsSheepSmooth-lipopolysaccharideVaccines, attenuated

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Veterinary Research due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2019, it was in position 6/141, thus managing to position itself as a Q1 (Primer Cuartil), in the category Veterinary Sciences. Notably, the journal is positioned above the 90th percentile.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-07-12:

  • WoS: 9
  • Scopus: 7
  • Europe PMC: 9

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-12:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 26.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 28 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 1.
  • The number of mentions on the social network X (formerly Twitter): 2 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.