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Grant support

This work received funding from Ministerio de Ciencia e Innovacion/Agencia Espanola de investigacion MCIN/AEI/https:// doi. org/ 10. 13039/ 50110 00110 33 and, as appropriate, by ERDF A way of making Europe by the European Union or by the European Union NextGenerationEU/PRTR (Grant agreement PID2020-114617RB-100), from Gobierno de Aragon (Department of I + D + I projects in priority lines, Grant agreement LMP58_21), and by University of Zaragoza (Grant agreement UZ2020-BIO-01). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Analysis of institutional authors

Calvo, Jorge HugoAuthorMarin, Clara MAuthor

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June 15, 2024
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Genomic and phenotypic analysis of invasive Streptococcus suis isolated in Spain reveals genetic diversification and associated virulence traits

Publicated to:Veterinary Research. 55 (1): 11- - 2024-01-24 55(1), DOI: 10.1186/s13567-024-01267-0

Authors: Uruen, Cristina; Fernandez, Ana; Arnal, Jose Luis; del Pozo, Mateo; Amoribieta, Maria Casas; de Blas, Ignacio; Jurado, Paula; Calvo, Jorge Hugo; Gottschalk, Marcelo; Gonzalez-Vazquez, Luis Daniel; Arenas, Miguel; Marin, Clara M; Arenas, Jesus

Affiliations

ARAID, Zaragoza, Spain - Author
CINBIO, Vigo, Spain - Author
Ctr Res & Technol Aragon CITA, Dept Anim Sci, Zaragoza, Spain - Author
Exopol Vet Diagnost & Autogenous Vaccine Lab, Zaragoza, Spain - Author
LABOPAT NUZOA SL, Labopat, Segovia, Spain - Author
Ovislab, Barcelona, Spain - Author
Univ Montreal, Fac Vet Med, Poultry Infect Dis Res Ctr, St Hyacinthe, PQ, Canada - Author
Univ Montreal, Fac Vet Med, Res Grp Infect Dis Prod Anim & Swine, St Hyacinthe, PQ, Canada - Author
Univ Vigo, Dept Biochem Genet & Immunol, Vigo, Spain - Author
Univ Zaragoza, Fac Vet, Unit Infect Dis, Zaragoza, Spain - Author
Univ Zaragoza, Fac Vet, Unit Microbiol & Immunol, Zaragoza, Spain - Author
Univ Zaragoza, Inst Agrofood Aragon, Ctr Res & Technol Aragon CITA, IA2, Zaragoza, Spain - Author
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Abstract

Streptococcus suis is a zoonotic pathogen that causes a major health problem in the pig production industry worldwide. Spain is one of the largest pig producers in the world. This work aimed to investigate the genetic and phenotypic features of invasive S. suis isolates recovered in Spain. A panel of 156 clinical isolates recovered from 13 Autonomous Communities, representing the major pig producers, were analysed. MLST and serotyping analysis revealed that most isolates (61.6%) were assigned to ST1 (26.3%), ST123 (18.6%), ST29 (9.6%), and ST3 (7.1%). Interestingly, 34 new STs were identified, indicating the emergence of novel genetic lineages. Serotypes 9 (27.6%) and 1 (21.8%) prevailed, followed by serotypes 7 (12.8%) and 2 (12.2%). Analysis of 13 virulence-associated genes showed significant associations between ST, serotype, virulence patterns, and clinical features, evidencing particular virulence traits associated with genetic clusters. The pangenome was generated, and the core genome was distributed in 7 Bayesian groups where each group included a variable set of over- and under-represented genes of different categories. The study provides comprehensive data and knowledge to improve the design of new vaccines, antimicrobial treatments, and bacterial typing approaches.

Keywords

AnimalsBayes theoremClustersDiseased pigsEpidemiologyGenetic recombinatioGenetic recombinationGenomicsIdentificationMultilocus sequence typingPcr assaySbpSpainStreptococcus suisSwineVirulenceVirulence factors

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Veterinary Research due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position 10/167, thus managing to position itself as a Q1 (Primer Cuartil), in the category Veterinary Sciences. Notably, the journal is positioned above the 90th percentile.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-07-16:

  • Google Scholar: 1
  • WoS: 8
  • Scopus: 5
  • Europe PMC: 7

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-16:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 15.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 17 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 11.
  • The number of mentions on the social network X (formerly Twitter): 4 (Altmetric).
  • The number of mentions in news outlets: 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: http://hdl.handle.net/10532/6846

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Canada.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Uruen, Cristina) and Last Author (Arenas, Jesús).

the author responsible for correspondence tasks has been Arenas, Jesús.