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Uterine serpin (SERPINA 14) correlates negatively with cytokine production at the foetal–maternal interface but not in the corpus luteum in pregnant dairy heifers experimentally infected with Neospora caninum

Publicado en:1. 53 (2): 556-558 - 2018-04-01 53(2), doi: 10.1111/rda.12937

Alabart J;

Afiliaciones

Centro de Investigación y Tecnología Agroalimentaria de Aragón - Entidad de origen
IRTA Investigación y Tecnología Agroalimentarias - Entidad de origen
Ministerio de Economia y CompetitividadSpanish Government [AGL2012-39830-C02-01/02] - Financiador
Transfer Bovine Reprod SLu, Barbastro, Spain - Autor o Coautor
Univ Autonoma Barcelona, Ctr Recerca Sanitat Anim, Inst Recerca & Tecnol Agroalimentaries, Barcelona, Spain - Autor o Coautor
Univ Autonoma Barcelona, Dept Sanitat & Anat Anim, Barcelona, Spain - Autor o Coautor
Univ Lleida, Agrotecnio Ctr, Lleida, Spain - Autor o Coautor
Univ Lleida, Dept Anim Sci, Lleida, Spain - Autor o Coautor
Univ Zaragoza, CITA, IA2, Zaragoza, Spain - Autor o Coautor
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Resúmen

Resúmen: This study examines gene expression patterns in dairy heifers experimentally infected with N. caninum during on Day 110 of pregnancy with live foetuses at euthanasia, 42 days later. The study population was constituted of four non-infected controls and three infected dams. Gene expression was determined on gamma interferon (IFN?), (Th1 pro-inflammatory cytokine), interleukin-4 (IL4) (Th2 pro-gestation cytokine) or interleukin-10 (IL10) (T regulatory cytokine) and the serine peptidase inhibitor SERPINA14 in intercaruncular, placental, uterine lymph node (UTLN) and luteal tissue samples. Intercaruncular SERPINA14 expression was negatively correlated with IFN? expression in cotyledon samples and with IL4 expression in UTLN. No relationships were detected between cytokine gene expression at the foetal-maternal interface and SERPINA14 expression in the luteal samples. Our findings suggest that gene expression of the uterine serpin SERPINA14 correlates negatively with the expression of Th1 and Th2 cytokines at the foetal-maternal interface but not in the corpus luteum.© 2017 Blackwell Verlag GmbH.

Palabras clave: bovine neosporosis; maternal immune response; placenta; Animal; Animals; Bovine; Bovine neosporosis; Cattle; Cattle disease; Cattle diseases; Coccidiosis; Corpus luteum; Cytokine; Cytokines; Female; Fetomaternal transfusion; Fetus; Gene expression regulation; Genetics; Maternal immune response; Maternal-fetal exchange; Metabolism; Neospora; Parasitology; Physiology; Placenta; Pregnancy; Pregnancy complication; Pregnancy complications, parasitic; Serine proteinase inhibitor; Serpins; Uterus; Veterinary medicine

Indicios de calidad

WoS Scopus by Scimago
Best Categ.Veterinary SciencesAnimal Science and Zoology
WoSScopus by ScimagoSPIFecytAgaurDialnetCircCapesMiar
IF1.6380.637--11.000
Rank36/141102/419
QQ2Q2-----A1
DD3D3-
TT1T1
PP26P25
Index ERIC-
Index Emergin-
Index AHCI-