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August 4, 2021
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Hepatic Synaptotagmin 1 is involved in the remodelling of liver plasma- membrane lipid composition and gene expression in male Apoe-deficient mice consuming a Western diet

Publicated to:Biochimica Et Biophysica Acta-Molecular And Cell Biology Of Lipids. 1865 (12): - 2020-12-01 1865(12), DOI: 10.1016/j.bbalip.2020.158790

Authors: Sancho-Knapik S; Pastor O; Barranquero C; Herrera Marcos LV; Guillén N; Arnal C; Gascón S; Navarro MA; Rodríguez-Yoldi MJ; Busto R; Lasunción MA; Osada J

Affiliations

CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Spain - Author
Departamento Bioquímica y Biología Molecular y Celular, Facultad de Veterinaria, Instituto de Investigación Sanitaria de Aragón (IISA), Universidad de Zaragoza, Spain - Author
Departamento de Farmacología y Fisiología, Facultad de Veterinaria, Instituto de Investigación Sanitaria de Aragón-Universidad de Zaragoza, Spain - Author
Departamento de Patología Animal, Facultad de Veterinaria, Instituto de Investigación Sanitaria de Aragón (IISA), Universidad de Zaragoza, Spain - Author
Instituto Agroalimentario de Aragón, CITA-Universidad de Zaragoza, Spain - Author
Servicio de Bioquímica Clínica, Unidad de Cuantificación y Caracterización Molecular, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Spain - Author
Servicio de Bioquímica-Investigación, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Spain - Author
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Abstract

Keywords

Abc transporter subfamily aAcetyl coenzyme a carboxylaseAcetyl coenzyme a carboxylase alphaAcetyl coenzyme a carboxylase betaAcyl coenzyme a desaturase 1Adverse eventAnimalAnimal cellAnimal tissueAnimalsApoe-deficient miceApolipoprotein a2Apolipoprotein eApolipoproteins eArticleC57bl mouseCarnitine palmitoyltransferase iCarnitine palmitoyltransferase iaCell membraneCholestanetriol 26 monooxygenaseCholesterol 7alpha monooxygenaseCholesterol blood levelCholesterol liver levelCytochrome p450 7b1Cytochrome p450 family 7Diacylglycerol acyltransferase 1Diacylglycerol acyltransferase 2Diet, westernFat dropletFatty liverGene deletionGene expressionGeneticsHep g2 cellsHepatic expressionHumansLipidLipid dropletsLipid metabolismLipoprotein metabolismLiverLiver cellLiver cell membraneLiver homogenateLiver microsomeLow density lipoprotein receptorLysophosphatidylcholineMaleMessenger rnaMetabolismMiceMice, inbred c57blMicrosomal triglyceride transfer proteinMouseMultidrug resistance protein 1NonhumanOpen reading framePeroxisome proliferator activated receptor gamma coactivator 1alphaPeroxisome proliferator activated receptor gamma coactivator 1betaPhosphatidylcholinePhosphatidylcholine sterol acyltransferasePhosphatidylethanolaminePlasma membrane lipidsPriority journalScavenger receptor biSynaptobrevin 2Synaptotagmin 1Synaptotagmin iSyt1Syt1 protein, mouseTissue distributionTriacylglycerolUnclassified drugVery low density lipoprotein cholesterolWestern diet

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Biochimica Et Biophysica Acta-Molecular And Cell Biology Of Lipids due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2020, it was in position 15/71, thus managing to position itself as a Q1 (Primer Cuartil), in the category Biophysics.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-07-03:

  • Scopus: 2

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-03:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 14.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 14 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 1.25.
  • The number of mentions on the social network X (formerly Twitter): 3 (Altmetric).