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This research was funded by Junta de Castilla y Leon under project VA148P23, with FEDER co-funding.

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Gonzalez-Garcia, VicenteAuthor

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February 12, 2025
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Bioactive Sesquiterpenoids from Santolina chamaecyparissus L. Flowers: Chemical Profiling and Antifungal Activity Against Neocosmospora Species

Publicated to:Plants-Basel. 14 (2): 235- - 2025-01-01 14(2), DOI: 10.3390/plants14020235

Authors: Sanchez-Hernandez, Eva; Martin-Gil, Jesus; Gonzalez-Garcia, Vicente; Casanova-Gascon, Jose; Martin-Ramos, Pablo

Affiliations

Ctr Invest & Tecnol Agroalimentaria Aragon CITA, Dept Sistemas Agr Forestales & Medio Ambiente, Avda Montanana 930, Zaragoza 50059, Spain - Author
Univ Valladolid, Dept Agr & Forestry Engn, ETSIIAA, Ave Madrid 44, Palencia 34004, Spain - Author
Univ Zaragoza CITA, Inst Agroalimentario Aragon IA2, Avda Montanana 930, Zaragoza 50059, Spain - Author
Univ Zaragoza, Univ Zaragoza CITA, Inst Agroalimentario Aragon IA2, Carretera Cuarte S-N, Huesca 22071, Spain - Author

Abstract

Santolina chamaecyparissus L. (cotton-lavender) is receiving increasing attention due to its potential for modern medicine and is considered both a functional food and nutraceutical. In this work, the phytochemical profile of its flower hydromethanolic extract was investigated by gas chromatography-mass spectrometry, and its applications as a biorational for crop protection were explored against Neocosmospora spp., both in vitro and in planta. The phytochemical profiling analysis identified several terpene groups. Among sesquiterpenoids, which constituted the major fraction (50.4%), compounds featuring cedrane skeleton (8-cedren-13-ol), aromadendrene skeleton (such as (-)-spathulenol, ledol, alloaromadendrene oxide, epiglobulol, and alloaromadendrene), hydroazulene skeleton (ledene oxide, isoledene, and 1,2,3,3a,8,8a-hexahydro-2,2,8-trimethyl-,(3a alpha,8 beta,8a alpha)-5,6-azulenedimethanol), or copaane skeleton (cis-alpha-copaene-8-ol) were predominant. Additional sesquiterpenoids included longiborneol and longifolene. The monoterpenoid fraction (1.51%) was represented by eucalyptol, (+)-4-carene, endoborneol, and 7-norbornenol. In vitro tests against N. falciformis and N. keratoplastica, two emerging soil phytopathogens, resulted in effective concentration EC90 values of 984.4 and 728.6 mu gmL-1, respectively. A higher dose (3000 mu gmL-1) was nonetheless required to achieve full protection in the in planta tests conducted on zucchini (Cucurbita pepo L.) cv. 'Diamant F1' and tomato (Solanum lycopersicum L.) cv. 'Optima F1' plants inoculated with N. falciformis by root dipping. The reported data indicate an antimicrobial activity comparable to that of fosetyl-Al and higher than that of azoxystrobin conventional fungicides, thus making the flower extract a promising bioactive product for organic farming and expanding S. chamaecyparissus potential applications.

Keywords

Antibacterial activityAntimicrobial propertiesAntioxidanAromadendrane skeletonBiological-activityBioplaguicidasBiorational pesticidesCompuestos bioquímicosConstituentsCotton-lavenderEspectrometría de masasEssential oilGc-ms analysisGuaiane-type sesquiterpenoidsHydroazulene frameworkLeaf oilNeocosmosporaProtección de las plantasSantolinaTomatoVolatile oilZucchinZucchini

Quality index

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-07:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 9.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 9 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 2.85.
  • The number of mentions on the social network X (formerly Twitter): 3 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: http://hdl.handle.net/10532/7448