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This work was supported by Ministeriode Cienciae Innovacion (Gobiernode Espana) (PID2020-113239RB-100) and Gobiernode Aragon (A07_23R). VP-Dhasapre doctoral contract from Diputacion General de Aragon (DGA).

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Noya, AgustiAuthorCarvajal-Serna, MelissaAuthor

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July 18, 2024
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Genotyping of rams based on melatonin receptor 1A gene polymorphisms: a tool in sire selection?

Publicated to:Reproduction Fertility And Development. 36 (9): RD23235- - 2024-01-01 36(9), DOI: 10.1071/rd23235

Authors: Pena-Delgado, Victoria; Noya, Agusti; Carvajal-Serna, Melissa; Canto, Francisco; Sanchez, Maria Carmen; Letosa, Eva; Vicente, Antonio; Morato, Ignacio; Macias, Angel; Abecia, Jose Alfonso; Casao, Adriana; Perez-Pe, Rosaura

Affiliations

Asociac Nacl Criadores Rasa Aragonesa ANGRA, Cabanera Real S-N, Zuera 50800, Spain - Author
Ctr Transferencia Agroalimentaria Aragon, Ctr Selecc & Reprod Anim, Barrio Movera 580, Zaragoza 50194, Spain - Author
Univ Zaragoza, Fac Vet, Grp BIOFITER IUCA, Miguel Servet 177, Zaragoza 50013, Spain - Author

Abstract

Context. Several polymorphisms in the melatonin receptor 1A gene (MTNR1A) have been related to reproductive performance in ovine. Aims. To investigate the effect of the RsaI and MnlI polymorphisms on ram seminal quality. Methods. Eighteen Rasa Aragonesa rams were genotyped for the RsaI (C/C, C/T, T/T) and MnlI (G/G, G/A, A/A) allelic variants of the MTNR1A gene. Individual ejaculates were analysed once a month throughout the whole year. Sperm motility, morphology, membrane integrity, levels of reactive oxygen species (ROS), phosphatidylserine (PS) inversion, DNA fragmentation and capacitation status were assessed. The effect of the season and polymorphisms on seminal quality was evaluated by mixed ANOVA. Key results. Both polymorphisms had an effect on membrane integrity and viable spermatozoa with low levels of ROS and without PS translocation, and RsaI also on motile and DNA-intact spermatozoa. An interaction between both polymorphisms was found, pointing to a negative effect on seminal quality of carrying the T or A allele in homozygosity. Differences were higher in the reproductive than in the non-reproductive season. Conclusions. Mutations substituting C by T and G by A at RsaI and MnlI polymorphic sites, respectively, in the MTNR1A gene in rams could decrease the seminal quality.

Keywords

AnimalsApoptosiAssociationCapacitationDna fragmentationFertilityGenotypeGenotypingMaleMelatonin receptorMnliMt1Mtnr1a genePolymorphism, geneticPolymorphism, single nucleotidePolymorphismsRamReactive oxygen speciesReceptor, melatonin, mt1Reproductive seasonalityRor-alphaRsaiSeasonalitySemen analysisSheepSire selectionSperm motilitySperm qualitSpermatozoa

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Reproduction Fertility And Development due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position 30/39, thus managing to position itself as a Q1 (Primer Cuartil), in the category Reproductive Biology.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-07-16:

  • WoS: 2
  • Scopus: 2

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-16:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 2.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 2 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 3.7.
  • The number of mentions on the social network X (formerly Twitter): 5 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.