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Grant support

We would like to acknowledge the Swiss National Science Foundation (SNSF) for funding the project within which the study was conducted (Grant number IZCOZ0_189896). We would also like to thank the Cost action INTEGRAPE (CA17111) for providing the opportunity to submit the project proposal and for all the exchange with colleagues that was possible via this COST action. Further thanks go to Patrik Schoenenberger and Luc Delmaire for support during plant production, Tara Smit-Sadki for help during leaf disc experiments and Jean-Philippe Burdet for fruitful discussions and tips. We would like to acknowledge our laboratory team, namely Nicole Imfeld and Marylin Cleroux for their support during laboratory analysis and Arnaud Pernet for technical assistance with climate chambers. Our thanks go as well to Katia Gindro for collaboration and support during plant production.

Analysis of institutional authors

Grimplet, JeromeAuthor

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June 16, 2024
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Unravelling molecular mechanisms involved in resistance priming against downy mildew (Plasmopara viticola) in grapevine (Vitis vinifera L.)

Publicated to:Scientific Reports. 13 (1): 14664- - 2023-09-06 13(1), DOI: 10.1038/s41598-023-41981-x

Authors: Vigneron, Nicolas; Grimplet, Jerome; Remolif, Eric; Rienth, Markus

Affiliations

Agroscope, Plant Protect, Mycol, Route Duillier 60, CH-1260 Nyon, Switzerland - Author
Ctr Invest & Tecnol Agroalimentaria Aragon, Dept Ciencia Vegetal, Avda Montanana 930, Zaragoza 50059, Spain - Author
Univ Sci & Art Western Switzerland, Changins Coll Viticulture & Enol, Route Duillier 60, CH-1260 Nyon, Switzerland - Author
Univ Zaragoza, Inst Agroalimentario Aragon IA2, CITA, Zaragoza 50013, Spain - Author

Abstract

Downy mildew (DM; Plasmopara viticola) is amongst the most severe fungal diseases in viticulture and the reason for the majority of fungicide applications. To reduce synthetic and copper-based fungicides, there is an urgent need for natural alternatives, which are being increasingly tested by the industry and the research community. However, their mode of action remains unclear. Therefore, our study aimed to investigate the transcriptomic changes induced by oregano essential oil vapour (OEOV) in DM-infected grapevines. OEOV was applied at different time points before and after DM infection to differentiate between a priming effect and a direct effect. Both pre-DM treatment with OEOV and post-infection treatment resulted in a significant reduction in DM sporulation. RNA-seq, followed by differential gene expression and weighted gene co-expression network analysis, identified co-expressed gene modules associated with secondary metabolism, pathogen recognition and response. Surprisingly, the molecular mechanisms underlying the efficiency of OEOV against DM appear to be independent of stilbene synthesis, and instead involve genes from a putative signalling pathway that has yet to be characterized. This study enhances our understanding of the molecular regulation of innate plant immunity and provides new insights into the mode of action of alternative natural antifungal agents.

Keywords

Disease resistanceExpressionHsfbLeavesStilbenesTranscription

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Scientific Reports due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position 25/134, thus managing to position itself as a Q1 (Primer Cuartil), in the category Multidisciplinary Sciences.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 3.59, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-16, the following number of citations:

  • WoS: 1
  • Scopus: 4

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-16:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 24.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 31 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 2.
  • The number of mentions on the social network X (formerly Twitter): 5 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: http://hdl.handle.net/10532/6560

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Switzerland.