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This project has been funded by the European Union's H2020 research and innovation program under Marie Sklodowska-Curie grant agreement No 801586; by the AGL2017-82987R project from the Spanish Government and the European Social Fund, and by the Aragon Regional Government (A20_23R) .

Analysis of institutional authors

Conesa, CeliaAuthor

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June 15, 2024
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Evaluation of in vitro antirotaviral activity of lactoferrin from different species using a human intestinal model

Publicated to:International Dairy Journal. 149 105818- - 2024-02-01 149(), DOI: 10.1016/j.idairyj.2023.105818

Authors: Graikini, Dimitra; Conesa, Celia; Abad, Ines; Perez, Maria Dolores; Sanchez, Lourdes

Affiliations

Inst Agroalimentario Aragon IA2 UNIZAR CITA, Zaragoza, Spain - Author
UNIV ZARAGOZA, FAC VET, DEPT PROD ANIM & CIENCIA ALIMENTOS, ZARAGOZA, SPAIN - Author

Abstract

Rotaviruses are the leading agents of severe diarrheal disease in infants and young children and complementary strategies to vaccination are needed. Therefore, we evaluated the activity of lactoferrin (LF) from different species against rotavirus in differentiated Caco-2/TC7 cells. The mechanism of rotavirus inhibition and the influence of iron saturation and sialic acid content were also investigated. Furthermore, the effect of bovine LF on Toll-like receptor expression (TLRs) during rotavirus infection was studied. LF presented high inhibitory activity against rotavirus above 8 mg mL-1, the bovine protein being the most potent. The antirotaviral mechanism of LF was mainly related to the virus neutralisation at an early step of infection. Interestingly, a direct relationship between rotavirus neutralisation activity and content of sialic acid in LFs was observed. Finally, the neutralisation of rotavirus by LF leaded to a decreased expression of TLRs in Caco-2/TC7 cells, with a more evident effect on TLR7.(c) 2023 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Keywords

Antibacterial activityBovine-milk lactoferrinCytokineExpressionProteinsRecognitionRecombinant human lactoferrinRotavirus infectionSialic-acidToll-like receptors

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal International Dairy Journal due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Food Science.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-07-20:

  • WoS: 11
  • Scopus: 12

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-20:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 13 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

    It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

    • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

    Leadership analysis of institutional authors

    There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Graikini, Dimitra) and Last Author (Sanchez, Lourdes).

    the author responsible for correspondence tasks has been Sanchez, Lourdes.